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Carpal tunnel syndrome (CTS) or median neuropathy at the wrist is a medical condition in which the median nerve is compressed at the wrist, leading to paresthesias, numbness and muscle weakness in the hand. The diagnosis of CTS is often misapplied to patients that have activity-related arm pain.

Most cases of CTS are idiopathic (without known cause), genetic factors determine most of the risk, and the role of arm use and other environmental factors is disputed.

Night symptoms and waking at night--the hallmark of this illness--can be managed effectively with night-time wrist splinting in most patients. The role of medications, including corticosteroid injection into the carpal canal, is unclear. Surgery to cut the transverse carpal ligament is effective at relieving symptoms and preventing ongoing nerve damage, but established nerve dysfunction in the form of static (constant) numbness, atrophy, or weakness are usually permanent and do not respond predictably to surgery.

Although the condition was first noted in medical literature in the early 20th century, the first use of the term “carpal tunnel syndrome” was in 1939.[1] The pathology was identified by physician Dr. George S. Phalen of the Cleveland Clinic after working with a group of patients in the 1950s and 1960s.[1] CTS became widely known among the general public in the 1990s because of the rapid expansion of office jobs.[2]

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